Butylated hydroxytoluene

Butylated hydroxytoluene - Names and Identifiers

Name	2,6-Di-tert-butyl-4-methylphenol
Synonyms	bht BHT dbpc T501 2,6-DBPC BHTOX-BHT ralox bht BHT (BAGS) bht (bags) Antioxidant 264 501 antioxidant antioxidant bht BHT,GRANULAR,FCC bht,granular,fcc Antioxidant T501 anti-oxidant bht Anitioxidant BHT dibutylmethylphenol butylhydroxytoluene ionol cp-antioxidant bht,granular,technical BHT,GRANULAR,TECHNICAL 2-butyl-3-methylphenol 3-butyl-4-methylphenol butylated hydroxytoluene butylhydroxytoluene bht Butylated Hydroxytoluene 2,6-Di-tert-buty-p-cresol butylated hydroxy toluene di-tert-butyl-para-cresol 2,6-di-tert-butyl-p-cresol 2,6-di-tert-butyl-4-cresol 2,6-di-tert. butyl-p-cresol di-tert-butylhydroxytoluene Rubber Anti aging agent 264 2,6-ditertiarybutylparacresol 2,6-Di-tert-butyl-4-methylphenol 4-methyl-2,6-di(tert-butyl)phenol 3,5-di-tert-4-butylhydroxytoluene 2,6-di-tert-butyl-4-methyl phenol BUTYLATEDHYDROXYTOLUENE,GRANULAR,NF butylatedhydroxytoluene,granular,nf bht (di-tert.-butyl-4-hydroxytoluol) 2,6,-di-tert-butyl-4-methylphenol cp 3,5-di-tert-4butylhydroxytoluene (bht) 2,6-di-(tert-butyl)-4-methylphynol-d21 Butylated hydroxytoluene Manufacturer 2,6-ditertbutyl-4-methyl phenol[128,37,0] 2,6-bis(1,1-dimethylethyl)-4-methylphenol 2,6-ditertiary-butyl-4-methyl-phenol(bht) bht 2,6 - di - tert - butyl -4- methyl phenol butyleret hydroxytoluen(2,6-di-tert-butyl-p-cresol)
CAS	128-37-0
EINECS	204-881-4
InChI	InChI=1/C15H24O/c1-10-8-11(14(2,3)4)13(16)12(9-10)15(5,6)7/h8-9,16H,1-7H3
InChIKey	NLZUEZXRPGMBCV-UHFFFAOYSA-N

Butylated hydroxytoluene - Physico-chemical Properties

Molecular Formula	C15H24O
Molar Mass	220.35
Density	1.048
Melting Point	69-73°C(lit.)
Boling Point	265°C(lit.)
Flash Point	127 °C
Water Solubility	insoluble
Solubility	Soluble in toluene, soluble in acetone, ethanol, benzene, ether, isopropanol, methanol, 2-butanone, ethylene glycol ether, petroleum ether and other organic solutions, insoluble in water and alkali solution.
Vapor Presure	<0.01 mm Hg ( 20 °C)
Vapor Density	7.6 (vs air)
Appearance	Colorless crystalline or white crystalline powder
Color	white
Odor	faint characteristic odor
Exposure Limit	ACGIH: TWA 2 mg/m3NIOSH: TWA 10 mg/m3
Merck	14,1548
BRN	1911640
pKa	pKa 14(H2Ot = 25c = 0.002 to 0.01) (Uncertain)
Storage Condition	2-8°C
Stability	Stable, but light-sensitive. Incompatible with acid chlorides, acid anhydrides, brass, copper, copper alloys, steel, bases, oxidizing agents. Combustible.
Refractive Index	1.4859
MDL	MFCD00011644
Physical and Chemical Properties	Density 1.048 melting point 69-71°C boiling point 265°C flash point 127°C water-soluble insoluble
Use	Used as rubber, plastic antioxidant, gasoline, transformer oil, turbine oil, animal and vegetable oil, food and other antioxidants

Butylated hydroxytoluene - Risk and Safety

Risk Codes	R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. R36/38 - Irritating to eyes and skin. R50/53 - Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S37/39 - Wear suitable gloves and eye/face protection S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. S60 - This material and its container must be disposed of as hazardous waste.
UN IDs	3077
WGK Germany	1
RTECS	GO7875000
FLUKA BRAND F CODES	8-10-23
TSCA	Yes
HS Code	29071900
Hazard Class	9
Packing Group	III
Toxicity	LD50 orally in mice: 1040 mg/kg (McOmie)

Butylated hydroxytoluene - Upstream Downstream Industry

Raw Materials

tert-Butanol
Ethyl Alcohol
Isobutene

Butylated hydroxytoluene - Reference

Reference

1. Lu Haohao, Jiao Rui, Huang Xuesong, et al. Comparative Study on Antioxidant Properties of 6-Gingerol and 6-Gingerol Oxime [J]. Modern Food Science and Technology 2015 031(009):106-111.
2. Zhang Mingyang, Han Kefei, Li Qing, et al. Screening of Biomarkers for Cerebral Ischemia Reperfusion Plasma Based on Free Fatty Acid Targeted Lipomics [J]. Chinese Journal of Pharmacy, 2020,055 (002):111-115.
3. Cao Wenli, Xue Yufei, Yang Yongxing, et al. Comparison of Antioxidant and Antimicrobial Activities of Different Solvent Extracts from Walnut Green Peel [J]. Chinese Brewing, 2019, 38(01):156-160.
4. Lan Wutao, Wu Xuehui, zhang Wen. Optimization of Polyphenol Purification Process of Oil Tea and Its Antioxidant Effect on Oil [J]. Journal of Southern Agriculture, 2019, 050(009):P.2058-2064.
5. Shu Ye Ting, Gao Jie, Peng Wenxiao, Li Yu, Gu Wei, Dong Jie, Chen Jun. Antioxidant Effect of Ganoderma lucidum Polysaccharide [J]. Journal of Nanjing University of Traditional Chinese Medicine, 2020,36(04):504-508.
6. Zhang Yun, Ma Shaoying, Lu Xu, et al. Isolation and Identification of Secreted Substances from Pea Roots and Their Allelopathy Effects [J]. Plant Physiology Communications, 2018, 3(3):3-3.
7. Li Huantong, Xu Zewen, Guo Xiaomin, study on Antioxidation of Rosemary Extract to Perilla Seed Oil [J]. Food Science and Technology, 2020, v.45;No.341(03):223-228.
8. Li Feng, Li Yijia, Li Qingxian, Guo Yanghao, Shi Xianai. Corosolic acid inhibits oxidative modification of human low density lipoprotein and protects vascular endothelial cells from oxidative damage [J]. Food Science, 2017,38(15):215-220.
9. Li Feng, Li Yijia, Li Qingxian, et al. Tripteryx Inhibits Oxidative Damage of LDL and HAEC Cells [J]. Chinese Pharmacological Bulletin, 2016, 032(011):1578-1584.
10. Ming Lisa, Tang Xiaoying, Liu Jianqiao, etc. Study on Refining and Antioxidant Activity of Total Ketones in Swertia roseum [J]. Food Industry, 2019, 40(02):66-70.
11. Tai Jia, Zou Junbo, Shi Yajun, et al. Study on Thermal Stability of Turmeric Volatile Oil and Its Antioxidant Screening [J]. Chinese Journal of Pharmacy, 2019(15).
12. Zhang Xuexin, Liu Zining, Wang Yuqian, Yang Yue. Study on the Difference of Polysaccharide Rate and Antioxidant Activity in Vitro of Different Varieties of Ganoderma lucidum [J]. Chinese Edible Fungi, 2021,40(01):79-83.
13. Yao Hongliang, Chen Xuanmin, Wang Xinlei, Shi Qixin, Qian Jinyi. Extraction and Purification of Flavonoids from Sweet Potato Leaves and Their Antioxidant Properties on Edible Oils [J]. Journal of Jinling Institute of Science and Technology, 2020,36(03):87-92.
14. Tahidul Islam, Xiaoming Yu, Baojun Xu, Phenolic profiles, antioxidant capacities and metal chelating ability of edible mushrooms commonly consumed in China, LWT-Food Science and Technology, Volume 72, 2016, Pages 423-431, ISSN 0023-6438, https://doi.org/
15. Liu, Y., Cai, C., Yao, Y. and Xu, B. (2019), Alteration of phenolic profiles and antioxidant capacities of common buckwheat and tartary buckwheat produced in China upon thermal processing. J. Sci. Food Agric., 99: 5565-5576. https://doi.org/10.1002/jsfa.98
16. [IF = 5.645] Xinran Li et al."An efficient homogenate-microwave-assisted extraction of flavonols and anthocyanins from blackcurrant marc: optimization using combination of Plackett-Burman design and Box-Behnken design." Ind Crop Prod. 2016 Dec;94:834
17. [IF = 4.952] Tahidul Islam et al."Phenolic profiles, antioxidant capacities and metal chelating ability of edible mushrooms commonly consumed in China." Lwt Food Sci Technol. 2016 Oct;72:423
18. [IF = 2.727] Jingyun Zheng et al."Total phenolics and antioxidants profiles of commonly consumed edit flowers in China." Int J Food Prop. 2018;21(1):1524-1540
19. [IF = 4.411] Tianming Zhao et al."Chemical Composition and Biological Activities of Essential Oils from the Leaves, Stems, and Roots of Kadsura coccinea." Molecules. 2021 Jan;26(20):6259
20. [IF = 4.311] Tinghao Jia et al."Effect of phenolic antioxidants on the thermal oxidation stability of high-energy-density fuel." Chem Eng Sci. 2022 Jan;247:117056
21. [IF = 3.935] Jingyun Zheng et al."A systematic investigation on free phenolic acids and flavonoids profiles of commonly consumed edible flowers in China." J Pharmaceut Biomed. 2019 Aug;172:268
22. [IF = 3.638] Yongxiang Liu et al."Alteration of phenolic profiles and antioxidant capacities of common buckwheat and tartary buckwheat produced in China upon thermal processing." J Sci Food Agr. 2019 Sep;99(12):5565-5576
23. [IF = 2.74] Hongyan Xue et al."The role of ALOX15B in heat stress-induced apoptosis of porcine sertoli cells." Theriogenology. 2022 Jun;185:6
24. [IF = 3.638] Fan-Bing Meng et al."Encapsulation of Zanthoxylum bungeanum essential oil to enhance flavor stability and inhibit lipid oxidation of Chinese-style sausage." Journal Of The Science Of Food And Agriculture. 2022 Jan 08
25. [IF = 2.408] Xiaonan Zhang et al."Chemical Composition, Antibacterial, antioxidant and Enzyme Inhibitory Activities of the Essential Oil from Leaves of Psidium guajava L .." CHEMISTRY & BIODIVERSITY 2022 Apr 12

Butylated hydroxytoluene - Nature

Open Data Verified Data

colorless crystal or white crystalline powder, odorless, tasteless. Soluble in ethanol (25%,25 ° C), acetone (40%), benzene (40%), soybean oil, cottonseed oil, insoluble in water, glycerol, propylene glycol. Light, thermal stability, heating can be volatilized with water vapor, the metal ion does not change color.

Last Update：2024-01-02 23:10:35

Butylated hydroxytoluene - Preparation Method

Open Data Verified Data

p-cresol and tert-butyl alcohol are dissolved by heating, and phosphoric acid is used as catalyst to react at a certain temperature. The reaction product is washed with sodium hydroxide solution to alkaline first, then washed with water to neutral, and finally distilled, recrystallization provides dibutyl hydroxytoluene. Or isobutylene mixed with cresol and concentrated sulfuric acid, reaction at a certain temperature for a certain time, and the crude product is neutralized, and then the crude product is dissolved in ethanol, adding thiourea, hot filtration, spin drying, obtained by drying.

Last Update：2022-01-01 10:08:46

Butylated hydroxytoluene - Standard

Authoritative Data Verified Data

This product is 2, 6-ditert-butyl (1, 1-dimethylethyl)-4-methylphenol. The content of C15H240 shall not be less than 98.5% calculated as anhydrous.

Last Update：2024-01-02 23:10:35

Butylated hydroxytoluene - Trait

Authoritative Data Verified Data

This product is colorless, white or off-white crystal or crystalline powder.
This product is easily soluble in acetone, soluble in ethanol, insoluble in water and propylene glycol.

freezing point

The freezing point of this product (General 0613) is 69~70°C.

absorption coefficient

take this product, precision weighing, plus ethanol dissolution and quantitative dilution to make a solution containing about 50mg per lm l, according to UV-visible spectrophotometry (General Rule 0 @ 1), the absorbance was measured at a wavelength of 278nm, and the absorption coefficient (dish) was 80. 0 to 90. 0.

Last Update：2022-01-01 11:19:25

Butylated hydroxytoluene - Introduction

Half lethal dose (mice, oral) 1040mg/kg, non-toxic.

Last Update：2022-10-16 17:13:06

Butylated hydroxytoluene - Use

Open Data Verified Data

BHT is an oil-soluble antioxidant widely used at home and abroad. Although it is toxic, it has strong antioxidant ability, good heat resistance and stability, no specific odor, no color reaction of metal ions, and low price, only 1/8~1/5 of BHA. Generally used in conjunction with BHA, and citric acid or other organic acids as a synergist. China's provisions can be used for edible oil, fried food, biscuits, instant noodles, nuts canned, dry fish products, the maximum use of 0. 2g/kg. This product also has a certain antibacterial effect, but weaker than BHA.

Last Update：2022-01-01 10:08:46

Butylated hydroxytoluene - Differential diagnosis

Authoritative Data Verified Data

in the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution.
The infrared absorption spectrum of this product should be consistent with that of the reference product (General rule 0402).

Last Update：2022-01-01 11:19:25

Butylated hydroxytoluene - Exam

Authoritative Data Verified Data

clarity and color of methanol solution

take this product l.O g, add methanol 10ml to dissolve, check according to law (General rule 0901 and General Rule 0 9 0 2 ) , the solution should be clear and colorless; If the color is developed, comparison with the yellow No. 3 Standard Colorimetric solution (General rule 0901 first method), should not be deeper.

sulfate

take this product lO. Add about 40ml of water, fully shake, filter, take the filtrate to check according to law (General rule 0802), and standard potassium sulfate solution 2. 0ml of the control solution should not be more concentrated (0.0 0 2%).

free ↑

take this product about 10g, precision weighing, add 0 .2 5% sodium hydroxide solution 50ml, heated and shaken in a water bath at 65°C for 5 minutes, cooled, filtered, the filtrate was placed in an iodine bottle, the filter residue was washed with 30ml water, and the solution was added to the iodine bottle, add 10ml of bromine titration solution (0.05mol/L) and 5ml of hydrochloric acid, immediately pack, fully shake, seal with 5ml of 10% potassium iodide solution, after placing in the dark place below 15°C for 15 minutes, the bottle was opened slightly, and the potassium iodide solution was placed in the iodine bottle. The bottle was immediately occluded, fully shaken, then sealed with water, and placed in the dark place for 5 minutes, sodium thiosulfate titration solution (0. lm o l/L) titration, near the end point, add 5ml of starch indicator solution, continue titration until the blue color disappears, and correct the titration result with blank test. Each lm l sodium thiosulfate titration solution (0. lm o l/L) is equivalent to 1 0.8 1! ^ (:7 into 0. The content of free phenol shall not exceed 0. 02% based on p-Cresol (C7H80).

Related substances

take about 0.2g of this product and add methanol to make a solution containing about 20mg per lm l as a test solution. Take lm l for precision measurement and put it in a 200ml measuring flask, methanol was added to dilute to the scale, shake, as a control solution. According to the thin layer chromatography (General 0502) test, absorb 10 ^ 1 of each of the above two solutions, respectively point on the same silica gel G thin layer plate, with dichloromethane as the developing solvent, spread over a distance of more than 15cm, dry, spray with 5% potassium ferricyanide solution-10% ferric chloride solution-water (10 : 20 : 70) mixed solution (ready for use), and immediately check. If the test solution shows impurity spots, the color should not be deeper (0 .5%) compared with the main spots displayed by the control solution.

moisture

take 5g of this product, according to the determination method of moisture (General rule 0832 first method 1), the water content shall not exceed 0 .1%.

ignition residue

The l.O g of this product shall be taken for inspection according to law (General rule 0841), and the remaining residue shall not exceed.

Heavy metals

Take 2. 5g of this product, inspection according to law (General Principles 0821 second law), containing heavy metals shall not exceed 4 parts per million.

arsenic salt

take 2.0g of this product, add calcium hydroxide 2.0g, mix, add a small amount of water, stir evenly, after drying, first burn with small fire to charring, then burn at 60CTC to Ash completely, and cool, add hydrochloric acid 5M l and water 23ml to dissolve, check according to law (General Principles 0822 The first law), should comply with the provisions (0.0001%).

Last Update：2022-01-01 11:19:26

Butylated hydroxytoluene - Content determination

Authoritative Data Verified Data

measured by high performance liquid chromatography (General 0512).

chromatographic conditions and system suitability test

silica gel bonded with eighteen alkyl silane was used as the filler; Methanol-water (9:1) was used as the mobile phase, and the detection wavelength was 278nm. The theoretical plate number is not less than 3000 based on the peak of dibutyl hydroxytoluene.

assay

take about 20mg of this product, precision weighing, put it in a 100ml measuring flask, add an appropriate amount of methanol to dissolve and dilute to the scale, shake well, take 10M1 of precision and inject it into human liquid chromatograph, record the chromatogram; Take the other two butyl hydroxy toluene reference substance, the same method. According to the external standard method to calculate the peak area, that is.

Last Update：2022-01-01 11:19:27

Butylated hydroxytoluene - Category

Authoritative Data Verified Data

pharmaceutical excipients, antioxidants.

Last Update：2022-01-01 11:19:27

Butylated hydroxytoluene - Storage

Authoritative Data Verified Data

sealed and stored in a cool and dry place.

Last Update：2022-01-01 11:19:28

Butylated hydroxytoluene - Reference Information

general phenolic antioxidant	Antioxidant 264 is an excellent general phenolic antioxidant, non-toxic, non-flammable, non-corrosive, storage stability, can inhibit or delay the oxidative degradation of plastic or rubber and prolong service life. Appearance is white or light yellow crystalline powder, soluble in benzene, toluene, methanol, ethanol, acetone, carbon tetrachloride, acetic acid, oil, ethyl ester and gasoline and other solvents, insoluble in water and dilute caustic soda solution. It is an excellent antioxidant additive for various petroleum products. It is widely used in various lubricating oils, gasoline, paraffin and various raw oils to prevent the increase of acid value or viscosity of lubricating oil and fuel oil. In food-grade plastics and packaged foods as food antioxidants, Stabilizers can delay the rancidity of food. Can also be used for polyethylene (PE), polystyrene (PS), PP (polypropylene), polyvinyl chloride, ABS resin, polyester, cellulose resin and foam (especially white or light colored products), food grade plastics, natural rubber, synthetic rubber (styrene, nitrile, polyurethane, cis-Polybutadiene Rubber, etc.), animal and vegetable fats and oils and animal and vegetable fats and oils containing food, cosmetics and other products. Reference dosage is generally 0.1%-1.0%.
physical properties	64% appearance white crystalline powder initial melting point ≥ 69 ℃ free phenol ≤ 0.02% burning residue ≤ 0.01% moisture ≤ 0.1% melting point 69.0-70.0 ℃ sulfide ≤ 0.02% arsenide ≤ 1 mg/kg
Application	as a food additive, it can effectively delay the rancidity of food, excellent antioxidants for secondary processing of gasoline, paraffin and other mineral oils; Especially antioxidants for food-grade plastics and polymer materials for packaged foods, and white or light-colored products of natural rubber and synthetic rubber, stabilizer
storage	as a general chemical storage in a dry and cool environment, recommended storage time is 12 months
Antioxidant	An antioxidant is an organic compound that inhibits or retards the thermal oxidation of polymers and other organic compounds in air. In general, it is very effective to add only 1% of an antioxidant in a small concentration. For example, food products are susceptible to Oxidative deterioration, and a small amount of an antioxidant may be added to prolong their storage time. Plastics, synthetic fibers and rubber and other polymer materials are prone to thermal oxidation degradation reaction, and the addition of antioxidant can maintain the excellent performance of polymer materials and prolong the service life. The addition of the antioxidant is better closer to the aging cycle, for example before the polymer is dried into a powder. Antioxidant PL-440 is a phosphite antioxidant with excellent performance, which can be used as antioxidant and heat stabilizer of high polymer, widely used in PVC, PET, ABS, polyolefin, nylon, PPO, PBT alloy, polystyrene and its other polymers. It can effectively improve the light stability, processing stability, mechanical strength, color stability and transparency of the product, and prolong the life of the product. PL-440 has the special function of stabilizing the melt viscosity of high polymer. The product is non-toxic and can be used in food packaging materials.
Antioxidant 565	Antioxidant 565 is a multi-functional polymer phenolic antioxidant, it is mainly applied to the post-processing stable treatment of unsaturated rubber, which is very effective for elastomer, and can protect the material from thermal oxidation degradation during production, processing and final use. Is a variety of resin excellent anti oxidant and photothermal stabilizer, with the added amount of small, low volatility, high color fastness, and can prevent the formation of gel characteristics.
content analysis	the internal standard solution is accurately weighed and 500mg of diphenylamine or 4-tert-butylphenol is dissolved in acetone and fixed to 250ml. Standard liquid accurate weighing standard BHT 100mg, dissolved in acetone and fixed volume to 50ml. Measure accurately weigh about 10mg of sample, dissolve in internal standard solution and set the volume to 50ml. The sample solution was injected into a gas chromatograph equipped with a hydrogen flame ion detector. A glass column (10% m x XE-60 I. D.) filled with a 1, 2, 6th carrier eropak 30, 100-200 mesh, was kept isothermal at 155 °c. The injector and detector temperatures were 225 °c and 250 °c, respectively. A nitrogen carrier gas was used at a flow rate of 30ml/min. The standard curve was drawn with the peak height of BHT and the peak height of internal standard solution at various concentrations, and then the content of BHT was obtained by referring to the standard curve.
Antioxidant 1010	Antioxidant 1010 is a macromolecular multifunctional hindered phenolic antioxidant, soluble in benzene, acetone, chloroform, insoluble in water. No pollution, no coloring, small volatility, good resistance to extraction. Widely used in polyethylene, polypropylene, polyoxymethylene, ABS resin, PS resin, PVC, plastic, rubber and petroleum products, polypropylene, polyethylene has excellent oxidation resistance. The service life of the article can be effectively extended. 1, with the auxiliary antioxidant DLTDP, antioxidant 168 and used in polypropylene resin, can significantly improve its thermal stability, is one of the most excellent varieties of phenolic antioxidants. 2, the general dosage is 0.1% ~ 0.5%, with the restriction of environmental protection regulations in foreign developed regions, the original tin products will gradually over to Wuxi products. 3, non-toxic, non-flammable, non-explosive, non-corrosive, good storage stability.
toxicity	ADI 0-0.3(FAO/WHO,2001). LD50 890mg/kg (rat, oral). GRAS(FDA,§ 182.3173,2000).
Antioxidant 168	Antioxidant 168 is an excellent phosphite Antioxidant with white powder appearance, soluble in benzene, chloroform, cyclohexane and other organic solvents, slightly soluble in ethanol, acetone, insoluble in water, alcohol and other polar solvents, slightly soluble in esters. Low toxicity, low volatility, high thermal stability , excellent hydrolysis resistance, can effectively decompose hydroperoxide produced in the thermal processing of polymeric materials. It has a good synergistic effect with Hindered amine antioxidant 1010 and 1076, and can improve the stability of the polymer material during thermal processing. With phenolic antioxidant compound preparation has reached more than ten, widely used in polyolefin (such as polyethylene, polypropylene) and olefin copolymer, polyamide, polycarbonate, PS resin, PVC, engineering plastics, rubber and stone oil products, ABS resin and other polymer materials. The compound can also be used for adhesives, natural or synthetic adhesive resins, etc. The general dosage is 0.1% ~ 1.0%.
usage limit	GB 2760-2001(g/kg): candy flavor 0.1; Edible oil, fried food, dried fish products, biscuits, instant noodles, instant noodles, canned nuts, cured meat products, 0.2; Breakfast cereals, 0.2 (mixed or used alone); Chewing gum 0.4; Gum base 1.0; Spices GMP. FAO/WHO(1984,mg/kg): General edible oil 200, milk fat 200 (not for direct consumption, also not for the preparation of milk and its products); Margarine 100. Japan (g/kg): Oil and Fat, preserved fish and shellfish products, etc. 0.2, immersion liquid 1 of frozen fish and shellfish, pectin 0.75. USDA (9CFR, § 318.7, § 381.147,2000%): dry sausage 0.003; Refined animal oil 0.01; Margarine 0.02; Poultry 0.01 (based on fat content). FDA (21CFR, § 172.115, § 172.615,§ 173.340,§ 181.24, § 182.3173; § 172.515;2000,mg/kg): Dehydrated potato chunks, flakes, dry breakfast cereals, 50; Shortening emulsion stabilizer 200; Potato Butters 10 (all based on total BHT and BHA); 0.1% for defoaming agents, etc.; 0.005% for food packaging materials; 0.5% for essential oils; gum Gum base 0.1%; A variety of fat-containing foods, 0.02% (in food fat content). EEC-HACSG: not for infants and young children food, unless supplemented with vitamin A.
Antioxidant 1076	Antioxidant 1076 is a non-polluting non-toxic hindered phenolic antioxidant, appearance of white or yellowish solid powder, soluble in benzene (57g), chloroform, cyclohexane, acetone (19g) and esters and other organic solvents, slightly soluble in methanol, ethanol, mineral oil, insoluble in water, light stable, not easy to change color, no pollution, no coloring, low volatility, water extraction resistance, good compatibility, high antioxidant efficiency, widely used in polyethylene, polypropylene, polyoxymethylene, ABS resin, polystyrene, polyvinyl chloride , engineering plastics, synthetic fibers, elastomers, adhesives, waxes, synthetic rubber and petroleum products. Prevents thermal oxidative degradation of the substrate. Addition is suitable at the stage of polymerization, production or end-use of the product. Often with the auxiliary antioxidant agent DLTP,168 and so on and play a synergistic effect, the antioxidant performance is better, the general dosage is 0.1% ~ 0.5%.
maximum allowable use amount of food additives maximum allowable residue standard	The Chinese name of the additive the Chinese name of the additive is allowed to use the food Chinese name of the additive function maximum allowable use amount (g/kg) maximum allowable residue (g/kg) butylated hydroxytoluene fried food antioxidant 0.2 butylated hydroxytoluene air-drying, drying, drying and other aquatic products antioxidant 0.2 butylated hydroxytoluene cured meat products (such as bacon, bacon, duck, Chinese ham, sausage, etc.) antioxidant 0.2 butylated hydroxytoluene biscuit antioxidant 0.2 butylated hydroxytoluene instant rice flour product antioxidant 0.2 butylated hydroxytoluene ready-to-eat cereals, including rolled oats (flakes) antioxidant 0.2 butylated hydroxytoluene gum base candy antioxidant 0.4 butylated hydroxytoluene nuts with canned seeds antioxidant 0.2 butylated hydroxytoluene fat, oil and emulsified fat products antioxidant 0.2
Antioxidant 1024	Antioxidant 1024 is a kind of antioxidant with excellent performance, soluble in methanol and acetone, slightly soluble in chloroform and ethyl acetate, insoluble in water, has the double structure of hindered phenol and hydrazide, and has the function of antioxidation and metal deactivation. It is a Metal deactivator, which does not produce color stain, and can be used alone or in combination with other general antioxidants, and has excellent synergistic effect. Suitable for polyethylene, polypropylene, polystyrene, polyamide, polyester, especially suitable for phenolic resin antioxidant agent, can effectively prevent the polymer due to the transition metal ions (such as catalyst residues) caused by the presence of self oxidation.
Chemical properties	white crystals. The color turned yellow and gradually darkened in light. Soluble in benzene, toluene, methanol, methyl ethyl ketone, ethanol, isopropanol, petroleum ether, linseed oil, insoluble in water and 10 ℃ caustic soda solution.
Use	used as rubber, plastic antioxidant, gasoline, transformer oil, turbine oil, animal and vegetable oil, additives for plastics BHT is an oil-soluble antioxidant which is widely used at home and abroad. Although it is toxic, it has strong antioxidant ability, good heat resistance and stability, neither specific odor nor color reaction of metal ions, and low price, only BHA 1/5~1/8, China is still used as the main antioxidant. Generally used in conjunction with BHA, and citric acid or other organic acids as a synergist. China's provisions can be used for edible oil, fried food, biscuits, instant noodles, boiled rice, canned nuts, dried fish products and cured meat products, the maximum use of 0.2g/kg. This product also has a certain antibacterial effect, but weaker than BHA. BHT can act as a feed antioxidant, protect the vitamins in the feed, and prevent the oxidative loss of fat and protein. Also has a certain antibacterial effect. The maximum dosage of 150g/t. BHT is an oil-soluble antioxidant widely used at home and abroad. Although it is toxic, it has strong antioxidant ability, good heat resistance and stability, neither specific odor nor color reaction of metal ions, and low price, only 1/8-1/5 of BHA, China is still used as the main antioxidant. Generally used in conjunction with BHA, and citric acid or other organic acids as a synergist. as a general-purpose phenolic antioxidant. Widely used in polymer materials, petroleum products and food processing industry. This product is a commonly used rubber antioxidant. It has a certain protective effect on heat and oxygen aging, and can also inhibit copper damage. Use alone does not have the ability to resist ozone, but with the anti-ozone agent and wax in combination can protect the weather of various factors on the damage of vulcanized rubber. It can also be used as a gelling inhibitor in styrene-butadiene rubber. In the general amount of rubber is 0.5-3 parts. When the dosage is increased to 3-5 parts, the frost will not be sprayed. This product can also be used as a stabilizer for the treatment and storage of synthetic rubber, and can be used for styrene butadiene rubber, cis butadiene Rubber, Ethylene Propylene Rubber, chloroprene rubber and other rubber. Antioxidant 264 is an effective antioxidant in some polymeric materials. This product in polyethylene, polyvinyl chloride (The amount of 0.01-0.1%) and polyvinyl ether is an effective stabilizer. Antioxidant 264 is an excellent antioxidant additive for various petroleum products. Good oil solubility. This product can also be used as an antioxidant for food processing industry, for containing more fat in food. The amount used is 0.2g/kg or less in oil and fat, butter, dried fish and shellfish, salted fish and shellfish, frozen cetaceans, etc., and 0.75g/kg or less in chewing gum. The usage of this product is immersion method, direct mixing method, mixed method and spray method after dissolving in ethanol. The United States, Japan and the European Community will be this product as a statutory feed additives, the European Community, the maximum amount of feed is 150ppm, can be used for a variety of feed. used in organic synthesis it is suitable for use as an antioxidant and antiadhesive additive for petroleum products, and an antioxidant for plastics and rubbers. It is used as antioxidant for petroleum products, fuel, rubber, plastic, food, feed, medicine, etc. Organic synthesis. Antioxidant
production method	After gasification, isobutanol is subjected to dehydration reaction in the presence of a catalyst to produce isobutylene, from the alkylation reaction with P-cresol. Kg/ton isobutanol (95%) 1400 p-Cresol (80%) 1000 (1) prepared from p-cresol and T-butanol. P-cresol and tert-butanol were heated and dissolved in a reaction kettle at 1:1.1 (molar ratio), and then the catalyst phosphoric acid was added to react at 65-70 ° C. With vigorous stirring. The reaction product was first washed with 10% sodium hydroxide solution until alkaline and then washed with water until neutral. The solvent was removed by distillation and the product was recrystallized from ethanol. (2) prepared from p-cresol and isobutylene. Isobutylene is introduced into a mixture of 98% p-cresol and 2% concentrated sulfuric acid according to the chemical formula, and reacted at 65-70 ° C. For 5H. The conversion of p-cresol can reach 95%. The acid was removed by washing with hot water at 60 °c, followed by washing with 10% NaOH followed by hot water until neutral to a crude product. The crude product was dissolved in 50% ethanol at 80-90 °c and 0.5% thiourea was added, filtered hot, spin dried, and dried to obtain a finished product. The yield is 90%-95%, the purity is 99.5%, and the melting point is more than 69.5 ° C. The series connection process of main and auxiliary columns is used industrially. First, P-cresol and catalyst are added into the main and auxiliary columns, and the temperature of the main column is controlled at 65-80 ℃, and the temperature of the auxiliary column is controlled at 50-70 ℃. Isobutene gas is introduced from the bottom of the main tower, and most of it reacts with P-cresol in the main tower, and the remaining part comes out from the top of the main tower, enters the bottom of the sub-tower, and further reacts with P-cresol. The reaction cycle of the main tower is controlled for another 4-5H. When the reaction is finished, the flow of Isobutene gas is stopped, A 20% NaOH solution was added and bubbled with compressed gas. The neutralized alkylated product was subjected to a distillation column (8 theoretical plates) to separate the crude product. The latter is dissolved in 95% ethanol, ion-exchanged to remove inorganic salts, cooled to 10-20 °c for crystallization, isolated and vacuum dried to give a product with a melting point greater than 69 °c. (1) P-cresol and tert-butanol are heated and dissolved in a reaction vessel at a molar ratio of 1:1.1. Under the action of phosphoric acid catalyst, the reaction was carried out at 65~70 ℃ with strong stirring; After the reaction was completed, the reaction product was washed with 10% sodium hydroxide solution until alkaline, and then washed with water until neutral; The solvent was removed, the final product was obtained by recrystallization from ethanol. CH3C6H4OH +(CH3)3COH[H3PO4]→ BHT(2) was reacted with isobutylene in a mixture of 98% p-cresol and 2% concentrated sulfuric acid at 65~70 ℃ for 5H; the acid was removed by washing with hot water at 60 °c, followed by washing with 10% NaOH followed by hot water until neutral to a crude product. The crude product was dissolved in 50% hot ethanol, and 0.5% thiourea was added. The product was obtained by hot filtration, spin drying and drying, and the yield was as high as 90% ~ 95%, purity 99.5%, melting point> 69.5. In the industry, the main and auxiliary columns are connected in series. First, P-cresol and the catalyst are added into the main and auxiliary columns, and the temperature of the main column is controlled at 65-80 ℃, and the temperature of the auxiliary column is controlled at 50-70 ℃. Isobutene gas is introduced from the bottom of the main column, and most of it reacts with P-cresol in the main column, and the remaining part exits from the top of the main column and enters the bottom of the sub-column to further react with P-cresol. The reaction period of the main column was controlled at 4-5H. When the reaction was finished, the flow of Isobutene gas was stopped, 20% NaOH solution was added, and bubbling with compressed gas was performed. The neutralized alkylated product was subjected to a distillation column (8 theoretical plates) to separate the crude product. The latter is dissolved in 95% ethanol, ion-exchanged to remove inorganic salts, cooled to 10-20 °c for crystallization, isolated and vacuum-dried to give a product with a melting point greater than 69 °c. CH3C6H4OH +(CH3)2C CH2[H2SO4] → BHT p-cresol reacts with isobutylene under pressure in the presence of concentrated sulfuric acid or phosphoric acid as catalyst and dehydrating agent alumina. The product was distilled and recrystallized from ethanol.
category	corrosive article
toxicity grade	poisoning
Acute toxicity	oral-rat LD50: 890 mg/kg; Abdominal injection-mouse LD50: 650 mg/kg
stimulation data	Skin-rabbits 500 mg/48 h moderate; eye-rabbit 100 mg/24 h moderate
explosive hazard characteristics	corrosive to skin and cornea; Strongly reactive with oxidant
flammability hazard characteristics	heat, flame flammable; Thermal decomposition stimulation smoke
storage and transportation characteristics	The warehouse is ventilated and dried at low temperature; It is stored separately from the oxidant
extinguishing agent	dry powder, carbon dioxide
Occupational Standard	TWA 10 mg/m3; Tel 20 mg/m3
(IARC) carcinogen classification	3 (Vol. 40, Sup 7) 1987
NIST chemical information	information provided by: webbook.nist.gov (external link)
EPA chemical substance information	information provided by: ofmpeb.epa.gov (external link)
spontaneous combustion temperature	878 ° F.
toxic substance data	information provided by: pubchem.ncbi.nlm.nih.gov (external link)

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